Death Domain Interactions in Death Receptor Signaling
نویسندگان
چکیده
منابع مشابه
Death receptor signaling.
Apoptosis or programmed cell death is a common property of multicellular organisms (Danial and Korsmeyer, 2004; Krammer, 2000). It can be triggered by a number of factors, including UVor γ-irradiation, chemotherapeutic drugs or signaling by death receptors (DR). The DR family is part of the tumor necrosis factor receptor superfamily (Bhardwaj and Aggarwal, 2003). Triggering members of the DR fa...
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A caspase 8-deficient subline (JB6) of human Jurkat cells can be killed by the oligomerization of Fas-associated protein with death domain (FADD). This cell death process is not accompanied by caspase activation, but by necrotic morphological changes. Here, we show that the death effector domain of FADD is responsible for the FADD-mediated necrotic pathway. This process was accompanied by a los...
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The timely resolution of inflammation prevents continued tissue damage after an initial insult. In the brain, the death of activated microglia by apoptosis has been proposed as one mechanism to resolve brain inflammation. How microglial death is regulated after activation is still unclear. We reported that exposure to lipopolysaccharide (LPS) and interleukin (IL)-13 together initially activates...
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Signaling from the transmembrane receptor Toll to Rel-related transcription factors regulates dorsoventral patterning of the Drosophila embryo, as well as larval and adult immunity. To identify additional pathway components, we have used double-stranded RNA interference to investigate Drosophila counterparts of genes that regulate the mammalian Rel family member NF-kappaB. Experiments in cultur...
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ژورنال
عنوان ژورنال: Journal of Biological Sciences
سال: 2004
ISSN: 1727-3048
DOI: 10.3923/jbs.2005.33.37